{"id":11440,"date":"2024-02-06T14:14:18","date_gmt":"2024-02-06T19:14:18","guid":{"rendered":"https:\/\/www.neuro-concept.ca\/?p=11440"},"modified":"2025-07-10T10:19:52","modified_gmt":"2025-07-10T14:19:52","slug":"la-neurogenese","status":"publish","type":"post","link":"https:\/\/www.neuro-concept.ca\/fr\/la-neurogenese\/","title":{"rendered":"Votre cerveau continue de fabriquer des neurones m\u00eame en vieillissant"},"content":{"rendered":"\t\t
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Il est \u00e0 noter que la question de la neurogen\u00e8se adulte ou formation de nouveaux neurones reste un sujet de d\u00e9bat parmi les scientifiques, et certaines controverses persistent. Cependant, de nombreuses \u00e9tudes convergent vers l’id\u00e9e que la neurogen\u00e8se adulte est pr\u00e9sente dans certaines parties du cerveau et peut \u00eatre modul\u00e9e par divers facteurs environnementaux et comportementaux. D\u2019autres \u00e9tudes limitent la neurogen\u00e8se au d\u00e9veloppement embryonnaire et \u00e0 l’enfance. Mais voil\u00e0 qu\u2019une \u00e9tude publi\u00e9e en 2019 semble mettre fin \u00e0 cette pol\u00e9mique et d\u00e9montre que la formation de nouveaux neurones peut \u00e9galement se produire dans certaines r\u00e9gions du cerveau chez les adultes. Ce travail rigoureux a \u00e9t\u00e9 r\u00e9alis\u00e9 dans des conditions m\u00e9thodologiques extr\u00eamement bien pens\u00e9es et met en avant la faille des processus utilis\u00e9es dans des \u00e9tudes ant\u00e9rieures expliquant l\u2019inconsistance des r\u00e9sultats.<\/span><\/p>

La principale zone du cerveau o\u00f9 la neurogen\u00e8se adulte a \u00e9t\u00e9 observ\u00e9e est l’hippocampe, une r\u00e9gion impliqu\u00e9e dans la m\u00e9moire et l’apprentissage. La neurogen\u00e8se dans l’hippocampe est un processus complexe qui implique la prolif\u00e9ration des cellules souches neurales, leur diff\u00e9renciation en neurones et leur int\u00e9gration dans les circuits neuronaux existants.<\/span><\/p>

Plusieurs facteurs influencent la neurogen\u00e8se adulte, tels que l’activit\u00e9 physique, l’environnement stimulant, le stress, le sommeil et m\u00eame certains facteurs hormonaux. Par exemple, l’exercice physique r\u00e9gulier a \u00e9t\u00e9 associ\u00e9 \u00e0 une augmentation de la neurogen\u00e8se, tandis que le stress chronique peut avoir des effets n\u00e9gatifs.<\/span><\/p>

La compr\u00e9hension de la neurogen\u00e8se adulte a des implications importantes pour la sant\u00e9 mentale, car elle pourrait \u00eatre li\u00e9e \u00e0 des processus tels que l’apprentissage, la m\u00e9moire et la plasticit\u00e9 c\u00e9r\u00e9brale. Une question importante qui se pose avec la neurogen\u00e8se adulte est son r\u00f4le dans les fonctions cognitives et son r\u00f4le au cours du vieillissement. Est-elle toujours pr\u00e9sente \u00e0 un \u00e2ge avanc\u00e9 comme \u00e0 plus de 70 ou 90 ans? Joue-t-elle un r\u00f4le dans le d\u00e9veloppement des maladies neurod\u00e9g\u00e9n\u00e9ratives? Dans cette nouvelle \u00e9tude, les tissus pr\u00e9lev\u00e9s sont issus de patients \u00e2g\u00e9s de 43 \u00e0 87 ans. Malgr\u00e9 l\u2019\u00e2ge des patients, les auteur\u00b7e\u00b7s ont bien mis en \u00e9vidence une fabrication de nouveaux neurones au sein de l\u2019hippocampe, mais uniquement au sein du gyrus dent\u00e9, et une absence de neurogen\u00e8se dans les autres zones de l\u2019hippocampe. Par ailleurs, les auteur.e\u00b7s ont \u00e9tudi\u00e9 la neurogen\u00e8se adulte chez des patients atteints de la maladie d\u2019Alzheimer \u00e0 diff\u00e9rents stades de la maladie. Ils mettent en \u00e9vidence une corr\u00e9lation entre l\u2019avanc\u00e9e de la maladie et le niveau de production et de maturation des nouveaux neurones dans l\u2019hippocampe, ouvrant ainsi de nouvelles voies de recherche sur la compr\u00e9hension de cette maladie.\u00a0 SI cette \u00e9tude met fin \u00e0 plus de 20 ans de controverse, cela ouvre de nouvelles probl\u00e9matiques \u00e0 \u00e9tudier pour mieux comprendre les m\u00e9canismes sous-jacents \u00e0 la neurogen\u00e8se adulte et son r\u00f4le fonctionnel dans le cerveau. Quelle est la proportion de nouveaux neurones produits au sein de l\u2019hippocampe? Comment s\u2019int\u00e8grent-ils dans les r\u00e9seaux pr\u00e9existants de l\u2019hippocampe? Remplacent-ils d\u2019anciens neurones ou se rajoutent-ils? Observe-t-on le m\u00eame processus dans les autres aires c\u00e9r\u00e9brales?<\/span><\/p>

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Moreno-Jim\u00e9nez EP, Flor-Garc\u00eda M, Terreros-Roncal J, R\u00e1bano A, Cafini F, Pallas-Bazarra N, \u00c1vila J, Llorens-Mart\u00edn M. Nat Med. 2019 Apr;25(4):554-560. doi: 10.1038\/s41591-019-0375-9. Epub 2019 Mar 25.<\/i><\/p>

Dynamics of hippocampal neurogenesis in adult humans. Spalding KL, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner HB, Bostr\u00f6m E, Westerlund I, Vial C, Buchholz BA, Possnert G, Mash DC, Druid H, Fris\u00e9n J. Cell. 2013 Jun 6;153(6):1219-1227. doi: 10.1016\/j.cell.2013.05.002.<\/i><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Il est \u00e0 noter que la question de la neurogen\u00e8se adulte ou formation de nouveaux neurones reste un sujet de d\u00e9bat parmi les scientifiques, et certaines controverses persistent. Cependant, de nombreuses \u00e9tudes convergent vers l’id\u00e9e que la neurogen\u00e8se adulte est pr\u00e9sente dans certaines parties du cerveau et peut \u00eatre modul\u00e9e par divers facteurs environnementaux et…<\/p>\n","protected":false},"author":1,"featured_media":11443,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[239],"tags":[],"class_list":["post-11440","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nLa neurogen\u00e8se adulte : fin de la controverse scientifique ?<\/title>\n<meta name=\"description\" content=\"Une \u00e9tude de 2019 confirme la formation de nouveaux neurones chez l\u2019adulte, en particulier dans l\u2019hippocampe. 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